Lab Mission
Why do seemingly similar tumours respond differently to radiotherapy?
Our laboratory uses radiation biology to reveal hidden biology that shapes tumour behaviour and treatment response. Although our discoveries emerge from radiotherapy, they seek to uncover fundamental biological principles that can transform precision cancer care.
Branch 1: Understanding How tumour become resistant
We investigate the fundamental biological barriers to effective radiotherapy, including genetic alterations, tumour cell plasticity and microenvironmental factors such as hypoxia. Our research seeks to uncover the mechanisms that enable tumours to survive treatment and drive radioresistance. By making these hidden biological processes measurable and clinically actionable, we aim to identify new opportunities to overcome treatment resistance and improve patient outcomes.
Branch 2: Predicting Which tumour respond to treatment
We develop biological and computational approaches to predict tumour response to radiotherapy and advance precision oncology. Our research integrates molecular biomarkers, tumour sex chromosome biology and quantitative modelling to identify previously overlooked sources of biological variation that influence treatment response. By combining laboratory science with large-scale clinical and genomic datasets, we seek to build more accurate, biologically informed models that support personalised treatment decisions.
Branch 2: Predicting Which tumour respond to treatment
We develop biological and computational approaches to predict tumour response to radiotherapy and advance precision oncology. Our research integrates molecular biomarkers, tumour sex chromosome biology and quantitative modelling to identify previously overlooked sources of biological variation that influence treatment response. By combining laboratory science with large-scale clinical and genomic datasets, we seek to build more accurate, biologically informed models that support personalised treatment decisions.
Branch 3: Transforming How biology informs radiotherapy
We translate biological discovery into clinical practice by integrating radiation biology across disciplines, technologies and healthcare systems. Our research extends beyond identifying new biomarkers to developing frameworks that reshape how radiotherapy is understood, delivered and implemented. Through multidisciplinary collaborations spanning clinical oncology, medical physics, artificial intelligence, health economics and the social sciences, we aim to ensure that biological knowledge informs every stage of precision radiotherapy: from scientific discovery to patient care.